North American Journal of Medical Sciences

ORIGINAL ARTICLE
Year
: 2013  |  Volume : 5  |  Issue : 10  |  Page : 604--608

Ribosomal protein s6-ps240 is expressed in lesional skin from patients with autoimmune skin blistering diseases


Ana Maria Abreu Velez1, Paul B Googe2, Michael S Howard4 
1 Georgia Dermatopathology Associates, Atlanta, Georgia, Georgia
2 Knoxville Dermatopathology Laboratory, Knoxville, Tennessee, USA

Correspondence Address:
Ana Maria Abreu Velez
Georgia Dermatopathology Associates, 1534 North Decatur Rd., NE; Suite 206; Atlanta, Georgia 30307-1000
Georgia

Background: The in situ signaling transduction within skin biopsies from patients affected by autoimmune skin blistering diseases is not well-characterized. Aim : In autoimmune skin blistering diseases, autoantibodies seem to trigger several intracellular signaling pathways and we investigated the presence of the phosphorylated form of ribosomal protein S6-pS240 within autoimmune skin blistering diseases biopsies. Materials and Methods: We utilized immunohistochemistry to evaluate the presence of S6-pS240 in lesional skin biopsies of patients affected by autoimmune skin blistering diseases including patients with an endemic and nonendemic pemphigus foliaceus (non EPF), with bullous pemphigoid (BP), pemphigus vulgaris (PV), dermatitis herpetiformis (DH), and the respective controls. Results: Most autoimmune bullous skin diseases biopsies stained positive for S6-pS240 around lesional blisters, including adjacent areas of the epidermis; and within upper dermal inflammatory infiltrates, and/or mesenchymal-endothelial cell junctions within the dermis. Conclusions: We document that S6-pS240 is expressed in lesional areas of skin biopsies from patients with autoimmune skin blistering diseases, as well as on eccrine glands and piloerector muscles. Thus, the role of this molecule in autoimmune skin blistering diseases warrants further study.


How to cite this article:
Velez AA, Googe PB, Howard MS. Ribosomal protein s6-ps240 is expressed in lesional skin from patients with autoimmune skin blistering diseases.North Am J Med Sci 2013;5:604-608


How to cite this URL:
Velez AA, Googe PB, Howard MS. Ribosomal protein s6-ps240 is expressed in lesional skin from patients with autoimmune skin blistering diseases. North Am J Med Sci [serial online] 2013 [cited 2022 Jun 25 ];5:604-608
Available from: https://www.najms.org/article.asp?issn=1947-2714;year=2013;volume=5;issue=10;spage=604;epage=608;aulast=Velez;type=0