North American Journal of Medical Sciences

ORIGINAL ARTICLE
Year
: 2012  |  Volume : 4  |  Issue : 4  |  Page : 180--184

Evaluation of TNF-α and IL-6 levels in obese and non-obese diabetics: Pre- and postinsulin effects


Rajeev Goyal1, Abul Faiz Faizy2, Sheelu S Siddiqui3, Monil Singhai4 
1 Department of Biochemistry, Government Medical College, Haldwani, Uttarakhand, India
2 Department of Biochemistry, Jawaharlal Nehru Medical College, AMU Aligarh, Uttar Pradesh, India
3 Department of Medicine, Jawaharlal Nehru Medical College, AMU Aligarh, Uttar Pradesh, India
4 Department of Microbiology, Government Medical College, Haldwani, Uttarakhand, India

Correspondence Address:
Monil Singhai
Department of Microbiology, Government Medical College, Haldwani, Uttarakhand - 263 139
India

Background: Type 2 diabetes (T2DM) mellitus is a serious implication of obesity. The effect of insulin therapy on levels of inflammatory markers among obese and non-obese diabetics has been inadequately studied. Aim: The study aimed to analyze the preinsulin and postinsulin levels of tumor necrosis factor α (TNF-α) and IL-6 in nonobese and obese T2DM patients. Materials and Methods: We assessed TNF-α and IL-6 levels in healthy controls (n=10) and diabetic patients (obese and nonobese; n=20 each) and analyzed the postinsulin effect on TNF-α and IL-6 levels after 24 and 48 weeks. TNF-α and IL-6 levels were also correlated with fasting plasma glucose of obese and nonobese diabetic patients after insulin therapy. Results: There is augmentation of TNF-α and IL-6 levels in diabetic patients and augmentation is more in obese than in nonobese diabetics. The obese group showed a significant decrease (P value<0.05) after 24 weeks of insulin therapy and an extremely significant decrease ( P<0.001) in TNF-α and IL-6 levels after 48 weeks of therapy. The nonobese group showed an extremely significant decrease ( P<0.001) in TNF-α and IL-6levels after 24 and 48 weeks both. Conclusion: There is augmented inflammation in diabetes and it is more in obese diabetics. Insulin therapy tends to counter this inflammation, but the response is delayed in obese diabetics.


How to cite this article:
Goyal R, Faizy AF, Siddiqui SS, Singhai M. Evaluation of TNF-α and IL-6 levels in obese and non-obese diabetics: Pre- and postinsulin effects.North Am J Med Sci 2012;4:180-184


How to cite this URL:
Goyal R, Faizy AF, Siddiqui SS, Singhai M. Evaluation of TNF-α and IL-6 levels in obese and non-obese diabetics: Pre- and postinsulin effects. North Am J Med Sci [serial online] 2012 [cited 2022 Oct 6 ];4:180-184
Available from: https://www.najms.org/article.asp?issn=1947-2714;year=2012;volume=4;issue=4;spage=180;epage=184;aulast=Goyal;type=0