North American Journal of Medical Sciences

ORIGINAL ARTICLE
Year
: 2011  |  Volume : 3  |  Issue : 4  |  Page : 176--178

No association between Val158Met of the COMT gene and susceptibility to schizophrenia in the Syrian population


Bassam Lajin1, Amal Alachkar2, Abdul Rezzak Hamzeh3, Roula Michati4, Hamid Alhaj5 
1 Department of Analytical Chemistry, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria
2 Department of Pharmacology, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria
3 Department of Biochemistry, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria
4 Ibn Khaldoon Psychiatric Hospital, Aleppo, Syria
5 Academic Psychiatry, Newcastle General Hospital, Newcastle NE4 6BE, United Kingdom

Correspondence Address:
Bassam Lajin
Department of Analytical Chemistry, Faculty of Pharmacy, University of Aleppo, Aleppo
Syria

Background : The Val158Met single nucleotide polymorphism of the COMT gene has been implicated in the aetiology of schizophrenia, although results from different populations have been conflicting. Aims: The aim of the present study was to investigate possible association between schizophrenia and Val158Met in a novel Arab population from Syria. Methods and Materials: 71 unrelated schizophrenic subjects (45 men) and 102 unrelated healthy controls (62 men) were recruited to take part in this case- control study. The Val158Met of the COMT gene was genotyped for patients and controls, using a new optimized PCR-RFLP method. Results: the results demonstrated that there is no statistically significant difference between the two groups. Conclusion: This study does not support that Val158Met has an influence on susceptibility for schizophrenia in this population.


How to cite this article:
Lajin B, Alachkar A, Hamzeh AR, Michati R, Alhaj H. No association between Val158Met of the COMT gene and susceptibility to schizophrenia in the Syrian population.North Am J Med Sci 2011;3:176-178


How to cite this URL:
Lajin B, Alachkar A, Hamzeh AR, Michati R, Alhaj H. No association between Val158Met of the COMT gene and susceptibility to schizophrenia in the Syrian population. North Am J Med Sci [serial online] 2011 [cited 2023 Jan 29 ];3:176-178
Available from: https://www.najms.org/article.asp?issn=1947-2714;year=2011;volume=3;issue=4;spage=176;epage=178;aulast=Lajin;type=0