North American Journal of Medical Sciences

ORIGINAL ARTICLE
Year
: 2011  |  Volume : 3  |  Issue : 2  |  Page : 82--84

Bullous allergic drug eruption with presence of myeloperoxidase and reorganization of the dermal vessels observed by using CD34 and collagen IV antibodies


Ana Maria Abreu-Velez1, Deo A Klein2, Bruce R Smoller3, Michael S Howard1 
1 Georgia Dermatopathology Associates, Atlanta, Georgia, USA
2 Statesboro Dermatology, Statesboro, Georgia, USA
3 Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

Correspondence Address:
Ana Maria Abreu-Velez
Georgia Dermatopathology Associates, Atlanta, Georgia, USA. 1534 North Decatur Road NE Atlanta, GA
USA

Context: Bullous allergic reactions are inflammatory skin disorders, presenting usually as a result of some type of reaction to medication. Case Report: A 67-year-old female was evaluated for the presence of diffuse patches of erythema, microvesiculation, vesicles, crusts, and oozing of sudden appearance on the extremities and on the rest of the body after taking sulfamethoxazole in combination with trimethoprim. Skin biopsies for hematoxylin and eosin examination, as well as for direct immunofluorescence and immunohistochemistry analysis were performed. H&E staining demonstrated classic features. Direct immunofluorescence revealed strong deposits of fibrinogen in the vessels of the skin. The immunohistochemistry stain showed strong positivity of myeloperoxidase within the blister cavity. The distribution of the vessels around the inflammatory process were noticed by using antibodies to CD34 as well to collagen IV. Conclusions: sulfamethoxazole is catalysed by CYP2C9 and/or myeloperoxidase. Thus, myeloperoxidase appears to be of importance in this disorder.


How to cite this article:
Abreu-Velez AM, Klein DA, Smoller BR, Howard MS. Bullous allergic drug eruption with presence of myeloperoxidase and reorganization of the dermal vessels observed by using CD34 and collagen IV antibodies.North Am J Med Sci 2011;3:82-84


How to cite this URL:
Abreu-Velez AM, Klein DA, Smoller BR, Howard MS. Bullous allergic drug eruption with presence of myeloperoxidase and reorganization of the dermal vessels observed by using CD34 and collagen IV antibodies. North Am J Med Sci [serial online] 2011 [cited 2022 May 17 ];3:82-84
Available from: https://www.najms.org/article.asp?issn=1947-2714;year=2011;volume=3;issue=2;spage=82;epage=84;aulast=Abreu-Velez;type=0