North American Journal of Medical Sciences

ORIGINAL ARTICLE
Year
: 2010  |  Volume : 2  |  Issue : 9  |  Page : 427--429

Post-natal maternal antiretroviral therapy and HIV prevalence among breast-fed infants in Benin, Nigeria


Paul E Imade1, Nkemjika O Uwakwe1, Richard Omoregie2, Nosakhare O Eghafona3 
1 Department of Medical Microbiology, University of Benin Teaching Hospital, Benin City, Nigeria
2 School of Medical Laboratory Sciences, University of Benin Teaching Hospital P.M.B 1111, Benin City, Nigeria
3 Department of Microbiology, Faculty of Life Sciences, University of Benin, Benin City, Nigeria

Correspondence Address:
Paul E Imade
Department of Medical Microbiology, University of Benin Teaching Hospital, Benin City
Nigeria

Background: Breastfeeding is an established mode of transmission of human immunodeficiency virus (HIV) infection resulting in clash between socio-cultural values and medical practice. Aims: This study aims to determine the effect of post-natal maternal antiretroviral therapy on transmission of HIV through breastfeeding. Patients and Methods: A total of 318 pregnant women were followed from pregnancy to 6 months post- partum. The women were divided into breast-fed and those who did not breast-feed, while the breast-fed were further divided into those on antiretroviral (ARV) and those not on ARV. After 6 months post-partum, dried blood spots were collected from infants born to these women and tested for HIV using polymerase chain reaction. Results: Generally, breast-feeding had 4 to 13 fold increase risk of transmission of HIV to infants (OR =7.079 95% CI = 3.768, 13.300; P <0.0001). However, among breast-fed infants, post-natal maternal ARV resulted in reduced prevalence of HIV compared to mothers who did not use ARV during breast-feeding (17.31% VS 92.00%; P<0.0001). Conclusion: The study demonstrates the effectiveness of post-natal maternal ARV. However, research into better feeding options to prevent mother to child transmission of HIV via breast-feeding is advocated.


How to cite this article:
Imade PE, Uwakwe NO, Omoregie R, Eghafona NO. Post-natal maternal antiretroviral therapy and HIV prevalence among breast-fed infants in Benin, Nigeria.North Am J Med Sci 2010;2:427-429


How to cite this URL:
Imade PE, Uwakwe NO, Omoregie R, Eghafona NO. Post-natal maternal antiretroviral therapy and HIV prevalence among breast-fed infants in Benin, Nigeria. North Am J Med Sci [serial online] 2010 [cited 2023 Jan 29 ];2:427-429
Available from: https://www.najms.org/article.asp?issn=1947-2714;year=2010;volume=2;issue=9;spage=427;epage=429;aulast=Imade;type=0