North American Journal of Medical Sciences

ORIGINAL ARTICLE
Year
: 2010  |  Volume : 2  |  Issue : 8  |  Page : 376--380

Histological and biochemical markers of the liver of Wistar rats on subchronic oral administration of green tea


Godwin Avwioro1, Sina Iyiola2, Benjamin Aghoghovwia1 
1 Faculty of Basic Medical Sciences, Delta State University, Abraka, Nigeria
2 Department of Histopathology, Obafemi Awolowo University Teaching Hospital, Ile-Ife, Nigeria

Correspondence Address:
Godwin Avwioro
Faculty of Basic Medical Science, Delta State University, Abraka
Nigeria

Background: Few articles have linked the consumption of green tea to certain liver diseases but several articles have disputed these assertions and the consumption of green tea has been on the increase. Aims: The effects of oral administration of green tea on the liver of Wistar rats were studied in order to compare biochemical findings with histological findings. Materials and Methods: 36 male and female Wistar albino rats were grouped into 6, consisting of 6 rats in each group. They were given 1%, 2%, 3%, 4% and 5% concentration of green tea in tap water for 42 days. The 6 th group was on normal diet and received 0% of the tea. Their blood samples were analyzed for total and conjugated bilirubin, total protein, albumin, globulin, alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase. The liver tissues were also processed for histological examination. Results: The liver tissues were essentially normal and similar to the control tissues. The biochemical parameters studied were also normal and similar to the results obtained from the control animals. Conclusion: Sub chronic consumption of green tea has no injurious effects on the liver of Wistar rats.


How to cite this article:
Avwioro G, Iyiola S, Aghoghovwia B. Histological and biochemical markers of the liver of Wistar rats on subchronic oral administration of green tea.North Am J Med Sci 2010;2:376-380


How to cite this URL:
Avwioro G, Iyiola S, Aghoghovwia B. Histological and biochemical markers of the liver of Wistar rats on subchronic oral administration of green tea. North Am J Med Sci [serial online] 2010 [cited 2022 May 21 ];2:376-380
Available from: https://www.najms.org/article.asp?issn=1947-2714;year=2010;volume=2;issue=8;spage=376;epage=380;aulast=Avwioro;type=0