| CASE REPORT |
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| Year : 2016 | Volume
: 8
| Issue : 7 | Page : 312-315 |
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Selective serotonin-norepinephrine reuptake inhibitors-induced Takotsubo cardiomyopathy
Rahul Vasudev1, Upamanyu Rampal2, Hiten Patel2, Kunal Patel2, Mahesh Bikkina2, Fayez Shamoon2
1 Department of Internal Medicine, New York Medical College, St Joseph's Regional Medical Center, New Jersey, USA
2 Department of Cardiology, New York Medical College, St Joseph's Regional Medical Center, New Jersey, USA
Correspondence Address:
Rahul Vasudev
Department of Internal Medicine, New York Medical College, St Joseph's Regional Medical Center, New Jersey - 07503
USA
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/1947-2714.187153
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Context: Takotsubo translates to "octopus pot" in Japanese. Takotsubo cardiomyopathy (TTC) is characterized by a transient regional systolic dysfunction of the left ventricle. Catecholamine excess is the one most studied and favored theories explaining the pathophysiology of TTC. Case Report: We present the case of a 52-year-old Hispanic female admitted for venlafaxine-induced TTC with a review literature on all the cases of Serotonin-norepinephrine reuptake inhibitors (SNRI)-associated TTC published so far. Conclusion: SNRI inhibit the reuptake of catecholamines into the presynaptic neuron, resulting in a net gain in the concentration of epinephrine and serotonin in the neuronal synapses and causing iatrogenic catecholamine excess, ultimately leading to TTC. |
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