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Year : 2016  |  Volume : 8  |  Issue : 6  |  Page : 250-251

Effect of statins on the mortality of bacteremic patients: A systematic review and meta-analysis of clinical trials

1 Department of Internal Medicine, Nanjing Medical University, Nanjing, Jiangsu, China
2 Department of Internal Medicine, Reading Health System, West Reading, Pennsylvania, USA
3 Department of Internal Medicine, Universal College of Medical Sciences, Bhairahawa, Nepal

Correspondence Address:
Dr. Paras Karmacharya
Department of Internal Medicine, Reading Health System, West Reading, Pennsylvania - 19611
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1947-2714.185034

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Background: Statins modify inflammatory cell signaling during the immune response to infection. This has been considered as a pleotropic effect. Effects of statins in inflammatory conditions such as bacteremia have been found to be controversial. Aims: We examined the effect of statins on the mortality of bacteremia patients. Material and Methods: Major databases were searched for the pertinent clinical trials. Results: Six cohort studies comprising 7553 patients were included. Hospital mortality was lower (15.36% vs 22.28%) in patients on statin. Conclusions: There may be a potential role of statins in similar inflammatory and infective conditions.

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