| ORIGINAL ARTICLE |
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| Year : 2016 | Volume
: 8
| Issue : 6 | Page : 250-251 |
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Effect of statins on the mortality of bacteremic patients: A systematic review and meta-analysis of clinical trials
Pragya Shrestha1, Dilli R Poudel2, Ranjan Pathak2, Sushil Ghimire2, Rashmi Dhital3, Madan R Aryal2, Maryam Mahmood2, Paras Karmacharya2
1 Department of Internal Medicine, Nanjing Medical University, Nanjing, Jiangsu, China
2 Department of Internal Medicine, Reading Health System, West Reading, Pennsylvania, USA
3 Department of Internal Medicine, Universal College of Medical Sciences, Bhairahawa, Nepal
Correspondence Address:
Dr. Paras Karmacharya
Department of Internal Medicine, Reading Health System, West Reading, Pennsylvania - 19611
USA
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/1947-2714.185034
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Background: Statins modify inflammatory cell signaling during the immune response to infection. This has been considered as a pleotropic effect. Effects of statins in inflammatory conditions such as bacteremia have been found to be controversial. Aims: We examined the effect of statins on the mortality of bacteremia patients. Material and Methods: Major databases were searched for the pertinent clinical trials. Results: Six cohort studies comprising 7553 patients were included. Hospital mortality was lower (15.36% vs 22.28%) in patients on statin. Conclusions: There may be a potential role of statins in similar inflammatory and infective conditions. |
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