| ORIGINAL ARTICLE |
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| Year : 2016 | Volume
: 8
| Issue : 2 | Page : 88-92 |
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Addition of selenium improves immunomodulative effects of glucan
Vaclav Vetvicka, Jana Vetvickova
Department of Pathology, University of Louisville, Louisville, Kentucky, USA
Correspondence Address:
Vaclav Vetvicka
Department of Pathology, University of Louisville, 511 S. Floyd, Louisville - 40292, Kentucky
USA
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/1947-2714.177311
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Background: Selenium (Se) is an established essential nutrient that plays a role in various biological processes including cancer development. Similarly, stimulation of immune reactions by β-glucans is well-documented. Aims: In the current study, we focused on the stimulation of phagocytosis and interleukin (IL)-2 production and on potentiation of anticancer immunity by a combination of glucan with two types of Se. Materials and Methods: Phagocytosis was evaluated using synthetic microspheres; cancer development was measured either using breast cancer cells or using lung cancer cells. Results: Using two different murine models of cancer, we showed that the Se/glucan combination strongly suppressed the growth of cancer, mostly probably via stimulation of immunity. Conclusions: A combination of glucan with Se offers superior stimulation of immunity and inhibition of cancer growth. |
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