| ORIGINAL ARTICLE |
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| Year : 2016 | Volume
: 8
| Issue : 1 | Page : 40-46 |
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The pathogenesis of rheumatoid arthritis is associated with milk or egg allergy
Jianjie Li1, Hao Yan1, He Chen1, Qiongmei Ji1, Shengguang Huang2, Pingchang Yang1, Zhigang Liu1, Bo Yang3
1 Institue of Allergy and Immunology, School of Medicine, Shen Zhen University, Shenzhen, China
2 Department of Rheumatism, Traditional Chinese Medicine, The Sixth People's Hospital of Shenzhen City, Shenzhen, China
3 Institue of Allergy and Immunology, School of Medicine; Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, China
Correspondence Address:
Bo Yang
Rm722, School of Medicine Building, Shenzhen University, Nan Hai Avenue 3688, Shenzhen
China
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/1947-2714.175206
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Background: Rheumatoid arthritis (RA) is a very complicated autoimmune disease with apparent synovial hyperplasia and cartilage and bone destruction. Aims: In the present study, we aimed to determine whether the pathogenesis of RA correlates with food allergy and which allergen(s) are relevant. Materials and Methods: We used type-II collagen (CII) to induce arthritis (collagen-induced arthritis, CIA) model in Wistar rats, and the development of arthritis was evaluated accordingly by scoring system. Proinflammatory cytokine levels in plasma were measured by enzyme-linked immunosorbent assay (ELISA), and concentrations of circulating immune complexes (CICs) were analyzed by C1q solid phase method. Furthermore, food-specific immunoglobulin G (IgG) and immunoglobulin E (IgE) levels were determined in the CIA model. Results: In the CIA model, we found that levels of tumor necrosis factor-alpha (TNF-a), interleukin (IL)-1, IL-6, and IL-17, as well as CICs, were elevated significantly. Moreover, concentrations of milk- or egg-specific IgG and IgE were enhanced strikingly in CIA rats. Conclusion: The results suggest that pathogenesis of RA correlates closely to increased egg- or milk-specific antibodies. |
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