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Year : 2015  |  Volume : 7  |  Issue : 9  |  Page : 379-383

Sarcoidosis and antiphospholipid syndrome: A systematic review of cases

1 Department of Internal Medicine, Reading Health System, Pennsylvania, USA
2 Department of Internal Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA
3 Department of Internal Medicine, Rapid City Regional Hospital, Rapid City, South Dakota, USA
4 Department of Oral Medicine, College of Dental Sciences, Kathmandu, Nepal
5 Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA

Correspondence Address:
Ranjan Pathak
Reading Health System, 6th Avenue and Spruce Street, West Reading, Pennsylvania - 19611
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1947-2714.166213

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Association between sarcoidosis and antiphospholipid syndrome (APS) is rare with few reported cases. We sought to systematically review the published cases of APS with sarcoidosis to better characterize the demographics, clinical characteristics, treatment, and the outcome of this association. Systematic electronic search for case report, case series, and related articles published until May 2014 was carried out and relevant data were extracted and analyzed. Four cases of APS with sarcoidosis were identified exclusively in females. These cases were seen in the sixth decade of life. Pulmonary embolism and central retinal artery occlusion were the presenting thrombotic events. All the patients were treated with lifelong anticoagulation with warfarin. During the median follow-up period of 5.5 months, additional thrombotic events were not observed. Although rare, sarcoidosis may be associated with APS. Further reporting of the cases will help to better establish this association, elucidate pathogenesis, and define clinical characteristics and outcomes.

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