Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Visit old site
Home Print this page Email this page Small font size Default font size Increase font size
Users Online: 405
Year : 2015  |  Volume : 7  |  Issue : 12  |  Page : 540-546

Histomolecular structural aspects of high endothelial vessels in lymph node and its significance in oral cancer and metastasis

1 Department of Oral and Maxillofacial Pathology, SIBAR Institute of Dental Sciences, Guntur, India
2 Dentistry Programme, Faculty of Medical Sciences, The University of the West Indies, Mona, Jamaica, West Indies
3 Department of Oral and Maxillofacial Pathology, Konaseema Dental College, Amalapuram, Andhra Pradesh, India

Correspondence Address:
Arvind Babu Rajendra Santosh
Dentistry Programme, Faculty of Medical Sciences, The University of the West Indies, Mona, Kingston, Jamaica, West Indies

Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1947-2714.172839

Rights and Permissions

Molecular cancer research studies focus on identifying diagnostic, screening, and metastatic indicators, and monitoring therapeutic responses. Migration of tumor cells and lymphocytes are important aspects in metastasis. High endothelial vessels are specialized histological structures identified in the blood vessels in lymphoid organs, which allow the migration of lymphocytes. In the recent decades, the role of high endothelial vessels is being addressed in cancer metastatic research. This review article is to highlight the histological and molecular structural aspects of high endothelial venules (HEVs) in the lymph node, and to demonstrate the role of HEVs in oral cancer metastasis, specifically oral and pharyngeal squamous cell carcinoma. The literature for the present paper were searched from the data sources such as Medline/PubMed, CINAHL plus, and gray literature sources from inception to May 2015. Searches were conducted using both free texts and medical subject headings related to the title of the present paper. Only the full text manuscripts of the search results that support the objective(s) of the paper and papers written in English were included. HEVs are unique structures that are identified in the lymphocytes and primarily assist in the lymphocytic migration from the blood stream into the lymph node. Understanding the histomolecular characteristics of HEV will allow researchers to develop novel therapeutic approaches in cancer tissues.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded951    
    Comments [Add]    
    Cited by others 2    

Recommend this journal