| REVIEW ARTICLE |
|
| Year : 2015 | Volume
: 7
| Issue : 12 | Page : 540-546 |
|
|
Histomolecular structural aspects of high endothelial vessels in lymph node and its significance in oral cancer and metastasis
Chandrasekar Poosarla1, Arvind Babu Rajendra Santosh2, Swetha Gudiseva1, Indira Meda3, Venkat Ramana Reddy Baddam1
1 Department of Oral and Maxillofacial Pathology, SIBAR Institute of Dental Sciences, Guntur, India
2 Dentistry Programme, Faculty of Medical Sciences, The University of the West Indies, Mona, Jamaica, West Indies
3 Department of Oral and Maxillofacial Pathology, Konaseema Dental College, Amalapuram, Andhra Pradesh, India
Correspondence Address:
Arvind Babu Rajendra Santosh
Dentistry Programme, Faculty of Medical Sciences, The University of the West Indies, Mona, Kingston, Jamaica, West Indies
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/1947-2714.172839
|
|
|
Molecular cancer research studies focus on identifying diagnostic, screening, and metastatic indicators, and monitoring therapeutic responses. Migration of tumor cells and lymphocytes are important aspects in metastasis. High endothelial vessels are specialized histological structures identified in the blood vessels in lymphoid organs, which allow the migration of lymphocytes. In the recent decades, the role of high endothelial vessels is being addressed in cancer metastatic research. This review article is to highlight the histological and molecular structural aspects of high endothelial venules (HEVs) in the lymph node, and to demonstrate the role of HEVs in oral cancer metastasis, specifically oral and pharyngeal squamous cell carcinoma. The literature for the present paper were searched from the data sources such as Medline/PubMed, CINAHL plus, and gray literature sources from inception to May 2015. Searches were conducted using both free texts and medical subject headings related to the title of the present paper. Only the full text manuscripts of the search results that support the objective(s) of the paper and papers written in English were included. HEVs are unique structures that are identified in the lymphocytes and primarily assist in the lymphocytic migration from the blood stream into the lymph node. Understanding the histomolecular characteristics of HEV will allow researchers to develop novel therapeutic approaches in cancer tissues. |
|
|
|
| [FULL TEXT] [PDF]* |
|
 |
|
