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Year : 2014  |  Volume : 6  |  Issue : 9  |  Page : 484-486

Hemophagocytic lymphohistiocytosis (hlh) associated with t-cell lymphomas: broadening our differential for fever of unknown origin

1 Department of Medicine, University of Vermont, Vermont, USA
2 Division of Hematology/Oncology, University of Vermont, Vermont, USA

Correspondence Address:
Sherrie Khadanga
Department of Medicine, University of Vermont, 111 Colchester Avenue, Fletcher 311, Burlington, Vermont-05401
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1947-2714.141656

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Context: Hemophagocytic lymphohistiocytosis (HLH), due to the excessive activity of histiocytes and lymphocytes, is a rare but aggressive disease that typically occurs in infancy but can be seen in all ages. If left untreated, patients with HLH may live for only a few months and die from multi-organ failure. Case Report: We present two cases of HLH diagnosis. Fever, spleen, and hepatic abnormalities were noted in both cases. Conclusion: Early diagnosis is the key and these two cases of similar etiology highlight how fever of unknown origin should force us to broaden our differential.

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