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Year : 2014  |  Volume : 6  |  Issue : 7  |  Page : 338-341

Acute eosinophilic myocarditis and hyper IgE in HIV Infection: A case report

1 Department of Cardiology in Seton Hall University School of Health and Medical Sciences, South Orange,New Jersey, USA
2 Department of Internal Medicine, Saint Michael's Medical Center, Newark, New Jersey, USA

Correspondence Address:
Hamid Shaaban
Department of Internal Medicine, Saint Michael's Medical Center, 111 Central Avenue, Newark, New Jersey 07102
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1947-2714.136918

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Context: Eosinophilic myocarditis is a rare cause of myocarditis. It is manifested histopathologically by diffuse or focal myocardial inflammation with eosinophilic infiltration, often in association with peripheral blood eosinophilia. Patients infected with Human Immunodeficiency Virus (HIV), especially those with lower CD4 counts, can occasionally have hyperimmunoglobulinemia E (Hyper IgE) and eosinophilia. Case Report: We report a case of a 29-year-old patient with Acquired Immunodeficiency Syndrome (AIDS) who had a persistent elevation of eosinophil counts and elevated IgE levels for a year prior to admission. He was presented to our emergency department with chest pain and laboratory tests revealed peripheral blood eosinophilia and elevated troponins. Coronary angiogram showed nonobstructive coronary artery disease. He then underwent cardiac magnetic resonance imaging which was consistent with an infiltrative myocarditis. After being put on steroid therapy, his peripheral eosinophilia resolved and his cardiac symptoms improved. Conclusion: Our case highlights that eosinophilia and Hyper IgE in HIV patients has the potential to contribute to end-organ damage.

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