|
 
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| REVIEW ARTICLE |
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| Year : 2013 | Volume
: 5
| Issue : 8 | Page : 460-464 |
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Spontaneous pneumomediastinum: Time for consensus
Sonu Sahni1, Sameer Verma1, Jinette Grullon2, Anthony Esquire3, Purvesh Patel1, Arunabh Talwar1
1 Department of Pulmonary, Critical Care and Sleep Medicine, North Shore - Long Island Jewish Health System, New Hyde Park, NY 11040, USA
2 School of Health and Natural Sciences, Mercy College, Dobbs Ferry, NY 10522, USA
3 Department of Medicine, Touro College of Osteopathic Medicine, Harlem, NY 10010, USA
| Date of Web Publication | 30-Aug-2013 |
Correspondence Address:
Arunabh Talwar
Department of Pulmonary, Critical Care and Sleep Medicine, North Shore - Long Island Jewish Health System, New Hyde Park, NY 11040
USA
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/1947-2714.117296
Pneumomediastinum (PM) is defined as the presence of free air in the mediastinal cavity. It is often regarded as a revealing sign of a more serious medical condition. PM is broken down into two categories, one, with an instigating event, referred to as secondary PM. The other is when free air is discovered in the mediastinal cavity without a clear etiology, referred to as spontaneous pneumomediastinum (SPM). Often misdiagnosed due to the vague nature of presenting symptoms, SPM must be part of the differential diagnosis of a chest pain patient to expedite discovery and if necessary, management. A MedLine/PubMED search was performed identifying all relevant articles with "SPM" in the title. Six case series were reviewed to determine what clinical scenario constitutes a possible case of SPM. Results showed that almost all patients with SPM exhibited some chest pain, but Hamman's crunch was present in only one-fifth of patients. Patients with certain pre-existing pulmonary diseases showed a greater propensity for the presence of free air in the mediastinal cavity. SPM must be diagnosed and managed promptly due to rare, but serious complications and any chest pain with an unknown etiology should contain SPM in the differential diagnosis. Keywords: Chest pain, Mediastinal emphysema, Spontaneous pneumomediastinum, Subcutaneous emphysema
How to cite this article:
Sahni S, Verma S, Grullon J, Esquire A, Patel P, Talwar A. Spontaneous pneumomediastinum: Time for consensus. North Am J Med Sci 2013;5:460-4 |
How to cite this URL:
Sahni S, Verma S, Grullon J, Esquire A, Patel P, Talwar A. Spontaneous pneumomediastinum: Time for consensus. North Am J Med Sci [serial online] 2013 [cited 2022 May 20];5:460-4. Available from: https://www.najms.org/text.asp?2013/5/8/460/117296 |
| Introduction | |  |
The mediastinal cavity is defined as the area demarcated by the pleural cavities laterally, the thoracic inlet superiorly and the diaphragm inferiorly. [1] Pneumomediastinum (PM) also referred to as mediastinal emphysema was originally described in 1819 by Laλnnec and [2],[3] is defined as the presence of free air in the mediastinal cavity. The discovery of free air in the mediastinal cavity is often thought of as a phenomenon secondary to a more serious medical condition. PM is broken down into two categories [Figure 1], one is as a result of trauma or caused iatrogenically due to endoscopic or other therapeutic procedures. Such cases are referred to as secondary PM, with a clear and causative factor. The second is the presence of free air in the mediastinal cavity without a clear etiology. In this review, we explore instances where PM is discovered without an identifiable source, which is referred to as spontaneous pneumomediastinum (SPM). The diagnosis of SPM is often obscured due to the fact that chest pain and dyspnea, two of the most common presenting symptoms, are a sign of a multitude of cardio-pulmonary pathologies. A consensus needs to be formed regarding presenting symptoms, clinical signs and medical conditions pre-disposing to the formation of SPM. Our results are presented along with a review of the literature outlining the clinical presentation, diagnostic algorithm as well as the therapeutic process in the setting of SPM. | Figure 1: Classification scheme of pneumomediastinum. Pneumomediastinum can be broken down into two main categories, secondary and idiopathic. Both categories have multiple causes
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The aim of this review is to outline the clinical scenario of a case of SPM. A MEDLINE/PubMed search was performed with the objective of identifying all articles published in the English language between January 1950 and February 2013 with "SPM" in the title. Combinations of medical subject heading terms including "SPM," "causes of SPM" and "symptoms of PM" were used. We largely selected publications from the last 10 years, but did not exclude any older publications that were widely referenced and highly regarded. We also searched the reference lists of articles identified by this search strategy and selected those we judged to be relevant. All pertinent reports were retrieved and the relative reference lists were systematically searched in order to identify any potential additional studies that could be included. All data was accessed between March and April 2013.
A total of six case series were selected and reviewed, which included a total of 201 patients that were admitted to their respected hospitals where an eventual diagnosis of SPM was established. [4],[5],[6],[7],[8],[9] The range of ages was 3-84 with an average age of 27.25 years (aggregate). Majority of patients, 74% (149 of 201) were male and 26% (52 of 201) were female. [4],[5],[6],[7],[8],[9]
| Features of Presentation | | |
Of the six case series reviewed, the most common presenting symptom was chest pain occurring in 75% of patients (150 of 201) [Table 1]. Other less common symptoms included dyspnea in 49%, [4],[5],[6],[7],[8] cough in 36%, [5],[6],[7]] neck pain in 36% [4],[5],[7],[8],[9] and dysphagia in 18%. [4],[5],[7],[8],[9] There were also sporadic complaints of odynophagia, lightheadedness, weakness, dysphonia, back pain, nasally sounding voice (rhinolalia) and central abdominal pain (epigastralgia) [4],[5],[6],[7],[8],[9] [Table 1]. | Table 1: Chief complaints prior to diagnosis of spontaneous pneumomediastinum
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Clinical examination of these patients revealed the presence of subcutaneous emphysema in 58% patients [4],[5],[6],[7],[8],[9] [Table 2]. However, the presence of Hamman's crunch, a crunching or bubbling sound over the mediastinum synchronous with the heart beat (Hamman's sign) [1],[2],[3] was only observed in 18% [4],[5],[7],[8],[9] of SPM patients. There were sporadic findings of neck swelling as well as associated pneumothorax. [6]
Pre-disposing factors
Of the six case series reviewed, four of them, totaling 156 patients, discussed possible triggering events or pre-disposing risk factors of SPM [Table 3]. Of the reporting case series, a positive history of smoking or tobacco use existed in 32% [5],[6] of patients. A pre-existing diagnosis of asthma existed in 18% [4],[5],[6],[7] of patients, interstitial lung disease (ILD) existed in 14% [6],[7] and a recent history of upper respiratory infection was present in 9% [4],[5] . A review of triggering events showed that emesis occurred in 14% [5],[6],[7]] of patients, strenuous physical activity in 9% [4],[5],[6],[7] of patients and bouts of cough in 7% [5],[6] of patients. | Table 3: Triggering event and pre-existing condition/risk factors for spontaneous pneumomediastinum
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Presentation
Though, this review focuses on the idiopathic form of PM it is important to mention that clinical presentation of SPM and mild secondary PM may be difficult to differentiate, so every effort must be made to eliminate possible secondary causes. Patients diagnosed to have SPM tend to be young, thin, males who present with arbitrary symptoms of chest pain, cough and dyspnea. [8] Due to the vague nature of these symptoms, the diagnosis requires a high-level of clinical suspicion. It has been estimated that up to 30% or more cases of SPM may go initially undiagnosed. [8]
Spontaneous mediastinum can also occur in a setting of a pre-existing pulmonary condition. A history of asthma and associated coughing bouts has been reported as a possible factor in the development of SPM in up to 25% of cases. [10] Chronic obstructive pulmonary disease (COPD), ILD and recent history of an upper respiratory tract infection have also all been reported. Up to 32% of patients in reporting case series had a history of tobacco use, primarily smoking. [5],[6]
SPM has also been linked to certain triggering events such as bouts of emesis, retching, cough and physical sporting activities [Table 3]. [5],[6],[7]] Though uncommon, SPM has also been identified in situations such as childbirth, [11] forceful straining during exercise, straining at passing stool, coughing and sneezing. [12]
| Diagnosis | | |
Majority of patients with eventual diagnosis of SPM presented with chest pain. The initial differential diagnosis is wide and includes pulmonary, cardiac, musculoskeletal and esophageal etiologies due to the vague nature of presenting symptoms. Eventually, majority causes can be safely diagnosed with a thorough history, detailed physical examination, electrocardiographic as well as radiographic or endoscopic assessment. [13] Though, it was Hamman in 1939 that first reported of his pathognomonic sign for subcutaneous emphysema, it is not always observed in cases of SPM. Review of the case series showed that subcutaneous emphysema is present in majority of patients, but only a small percentage show a positive Hamman's sign. [4],[5],[7],[8] To make a definitive diagnosis, diagnostic imaging must be part of the work-up [Figure 2]. Chest radiography is almost always the primary imaging technique of choice, which can identify SPM in up to 90% of cases. [8] There are certain radiological signs to look for in suspected cases of PM. If there is sufficient air, the thymus can become elevated to produce the thymic sail sign, which is more common in a pediatric population. [14] Another classical sign indicating free air in the mediastinum is called the "ring sign," which is caused by air surrounding the pulmonary artery or either of its main branches, especially when the air surrounds the intramediastinal segment of the right pulmonary artery. [15] If a definitive diagnosis can be made with a plain chest film, no further testing is needed and the patient may be observed. However, in cases where chest film is not apparent computed tomography (CT) scanning is always diagnostic. [16]  | Figure 2: Diagnostic workflow for patients highly suspicious of spontaneous pneumomediastinum. Chest pain suspicious of spontaneous pneumomediastinum can be initially evaluated with a plain chest radiograph. Result depending, further investigations may be ordered
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| Management | | |
Usually, SPM is not part of the differential diagnosis and it is treated as another causative factor of chest pain, dyspnea and wheezing, i.e., asthma or COPD exacerbation. SPM usually follows a benign course and management is, in most cases conservative. Majority of patients admitted to the hospital are treated with analgesics, rest, oxygen therapy, bronchodilators and occasionally antibiotic treatment. [4] Pure oxygen treatment increases the diffusion pressure of nitrogen in the interstitium and promotes rapid absorption of the free air. [17] If any pre-disposing condition (asthma, infection, airway obstruction, etc.) is responsive to pharmacological management then SPM is self-limiting. [18]
Once released from the hospital SPM patients may be followed on an out-patient basis with serial chest radiographs or CT scans until complete resolution. In addition, bed rest is a vital part of conservative management to help expedite the resolution of SPM to avoid any further complications.
| Complications | | |
Though complications are rare in SPM, prompt diagnosis and management are imperative to prevent further progression. In laboratory experiments induced by Macklin and Macklin, SPM showed a possibility to convert to tension or malignant PM, [17] which may lead to cardiac or great vessel compression. Cases of persistent mediastinal free air have been reported that suggest air leaking into the pericardial sac can result in pneumopericardium. [18] Similar mechanisms can lead to free air reaching the retropharyngeal and the retroperitoneal spaces. [18] Air can also easily pass through the cervical region due to the close proximity between the mediastinum and the upper spine which may result in pneumorrhachis, free air in the spinal canal. [19] Airflow movement through pleural structures can explain the onset of pneumothorax or even tension pneumothorax; [18] however, its occurrence is rare. If such complications arise they should be treated emergently with chest tube placement or surgical decompression. [20]
| Discussion | | |
The mediastinal cavity is defined as area demarcated by the pleural cavities laterally, the thoracic inlet superiorly and the diaphragm inferiorly. [1] PM refers to the presence of free air within the mediastinal cavity. SPM, which was initially described by Laennec in 1819, was further characterized in case series by Hamman in 1939. [10] SPM is a rare condition reported with incidence of less than 1:44,000 and often follows a benign course. [5] Though many pre-existing medical conditions have been thought to pre-dispose to the development of SPM, the pathophysiologic process is the same. It is thought that sudden changes in pressure in the thoracic cavity may precede the development of SPM due to the alveolar leakage. The pathogenesis of SPM was first proposed by Macklin in 1939, who thought that alveolar ruptures lead to air dissection along bronchovascular sheaths, which with eventual spreading of this pulmonary interstitial emphysema into the mediastinum. [21],[17] The Macklin effect reported in 1944, the PM pathophysiology, is broken down into a three step process, alveolar ruptures, air dissection along bronchovascular sheaths and spreading of this pulmonary interstitial emphysema into the mediastinum. [21],[17]
The Macklin effect is also involved in secondary PM such as in blunt traumatic PM, but also in PM arising in various conditions, such as respiratory distress syndromes, barotraumas, asthma crises, mechanical ventilation and valsalva maneuvers (parturition, intense vomiting and epileptic seizures). [6],[7],[8],[11],[12]
| Conclusion | | |
SPM is a rare condition that often follows a benign course and is often under diagnosed due to a clinical presentation similar to many respiratory pathologies. Due to rare but serious complications, diagnosis and expectant management are necessary. Development of SPM is often seen in young males who are smokers or patients that have a pre-existing pulmonary condition. In SPM patients, chest pain and dyspnea are the predominant symptoms often clouding the differential diagnosis. The pathognomonic sign of Hamman's crunch is only be present in a small percentage of SPM patients, but it does not rule out the need for further investigations. In any patient, especially actively smoking young males, pulmonary patients or in patients that have a recent medical history with a high clinical suspicion, a full comprehensive radiological assessment must be performed to rule out presence of SPM due to its possible complications.
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[Figure 1], [Figure 2]
[Table 1], [Table 2], [Table 3]
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Spontaneous pneumomediastinum associated with COVID-19: Rare complication of 2020 pandemic |
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| Nieves-Ortiz Arnaldo A,Fonseca-Ferrer Vanessa,Hernández-Moya Kyomara,Mendez Ramirez Keren,Ayala-Rivera Jose,Delgado Marangely,Garcia-Puebla Juan,Fernández-Medero Rosangela,Fernandez-Gonzalez Ricardo | | Journal of Pulmonology and Respiratory Research. 2020; 4(1): 018 | | [Pubmed] | [DOI] | | | 36 |
Case Report: Pneumothorax and Pneumomediastinum as Uncommon Complications of COVID-19 Pneumonia—Literature Review |
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| Alvaro Quincho-Lopez,Dania L. Quincho-Lopez,Fernando D. Hurtado-Medina | | The American Journal of Tropical Medicine and Hygiene. 2020; 103(3): 1170 | | [Pubmed] | [DOI] | | | 37 |
An Intriguing Case of Pneumoperitoneum In a Patient With COVID-19: Do All Pneumoperitoneum Cases Need Surgery? |
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| Munish Sharma,Pratima Ojha,Pahnwat T Taweesedt,Iqbal Ratnani,Salim Surani | | Cureus. 2020; | | [Pubmed] | [DOI] | | | 38 |
Idiopathic pneumomediastinum – case report and review of the literature |
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| Iv. Novakov | | Trakia Journal of Sciences. 2019; 17(3): 269 | | [Pubmed] | [DOI] | | | 39 |
Imaging Findings Related to the Valsalva Maneuver in Head and Neck Radiology |
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| A.A. Madhavan,C.M. Carr,M.L. Carlson,J.I. Lane | | American Journal of Neuroradiology. 2019; | | [Pubmed] | [DOI] | | | 40 |
Neumomediastino asociado a crisis asmática en el adulto. Reporte de dos casos |
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| Andrés Fernando Rodríguez-Gutiérrez,José A Urrego,Álvaro J Burgos,Laura Navarro-Monterroza,Danna Moros-Suárez,Iván Moyano,Sol Naranjo-Casallas,Nathalia Muñoz-Ortega | | NCT Neumología y Cirugía de Tórax. 2019; 78(1): 41 | | [Pubmed] | [DOI] | | | 41 |
Neumomediastino espontáneo: reporte de caso en un paciente con asma bronquial |
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| Brenda Garduño Orbe,Jahzeel Balanzar Maldonado,Wendy Esteban Gómez,Elizabeth Silva Meneses,Luis Arzeta Valderrama | | Atención Familiar. 2019; 26(3): 114 | | [Pubmed] | [DOI] | | | 42 |
Seltene Ursache für akuten Brustschmerz und Dyspnoe bei jungen Männern |
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| W. L. Wagner,A. Rothermel,T. Mokry,C. Sommerer,C. P. Heußel,H.-U. Kauczor | | Medizinische Klinik - Intensivmedizin und Notfallmedizin. 2019; | | [Pubmed] | [DOI] | | | 43 |
Intrapartum spontaneous pneumomediastinum with subcutaneous emphysema - Management and recommendations to prevent recurrence in future pregnancies |
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| N. Wilson-Baig,K. Bhatia,P. Kochhar,S. Bonner | | International Journal of Obstetric Anesthesia. 2019; | | [Pubmed] | [DOI] | | | 44 |
Cocaine-Induced Pneumopericardium: Safe for Discharge? A Case Report and Literature Review |
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| Xavier Galloo,Jan Stroobants,David Yeo,Esmael El-Abdellati | | Case Reports in Cardiology. 2019; 2019: 1 | | [Pubmed] | [DOI] | | | 45 |
A Case Report of Acute Airway Compromise due to Subcutaneous Emphysema |
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| David Olmstead,Gary Gelfand,Ian Anderson,John B. Kortbeek | | Case Reports in Medicine. 2018; 2018: 1 | | [Pubmed] | [DOI] | | | 46 |
A case of pneumomediastinum managed a regional hospital in Guyana |
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| Tameshwar K Algu | | Tropical Doctor. 2018; 48(3): 245 | | [Pubmed] | [DOI] | | | 47 |
Pneumomediastinum revisited: we should reconsider usual classification |
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| Melanie Dechamps,Lieven De Smedt,Said Hachimi Idrissi | | Acta Clinica Belgica. 2018; : 1 | | [Pubmed] | [DOI] | | | 48 |
Hammanæs syndrome (spontaneous pneumomediastinum presenting as subcutaneous emphysema): A rare case of the emergency department and review of the literature |
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| Konstantinos Grapatsas,Zoi Tsilogianni,Vasileios Leivaditis,Sotirios Kotoulas,Christoforos Kotoulas,Efstratios Koletsis,Ilias Stylianos Iliadis,Manfred Dahm,Georgia Trakada,Lemonia Veletza,Anastasios Kallianos,Haidong Huang,Christoforos Kosmidis,Michael Karanikas,Vasilis Thomaidis,Konstantinos Porpodis,Paul Zarogoulidis | | Respiratory Medicine Case Reports. 2018; 23: 63 | | [Pubmed] | [DOI] | | | 49 |
Bilateral spontaneous pneumothoraces with spontaneous pneumomediastinum: An intravenous methamphetamine complication |
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| Daniel Guck,Ryan Munyon | | Respiratory Medicine Case Reports. 2018; 25: 4 | | [Pubmed] | [DOI] | | | 50 |
Spontaneous pneumomediastinum in a healthy young female: A case report and literature review |
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| Ahmed Dirweesh,Chikezie Alvarez,Muhammad Khan,Donald Christmas | | Respiratory Medicine Case Reports. 2017; 20: 129 | | [Pubmed] | [DOI] | | | 51 |
Spontaneous Pneumomediastinum Complicating Severe Acute Asthma Exacerbation in Adult Patients. |
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| Andrea Vianello,Marco Caminati,Fulvia Chieco-Bianchi,Maria Rita Marchi,Stefania Vio,Giovanna Arcaro,Silvia Iovino,Fausto Braccioni,Beatrice Molena,Cristian Turato,Piera Peditto,Laura Battistella,Federico Gallan,Gianenrico Senna | | Journal of Asthma. 2017; : 00 | | [Pubmed] | [DOI] | | | 52 |
Spontaneous Pneumomediastinum: Case Presentation to a College Student Health Clinic |
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| P. Hunter Spotts | | Journal of American College Health. 2017; : 00 | | [Pubmed] | [DOI] | | | 53 |
Diagnosis and treatment of spontaneous pneumomediastinum: experience at a single institution for 10 years |
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| In-Hag Song,Seock Yeol Lee,Seung Jin Lee,Won Suk Choi | | General Thoracic and Cardiovascular Surgery. 2017; 65(5): 280 | | [Pubmed] | [DOI] | | | 54 |
Management of spontaneous pneumomediastinum: Are hospitalization and prophylactic antibiotics needed? |
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| Masatomo Ebina,Akira Inoue,Akihiro Takaba,Koichi Ariyoshi | | The American Journal of Emergency Medicine. 2017; | | [Pubmed] | [DOI] | | | 55 |
Diffuse Subcutaneous Emphysema and Pneumomediastinum Secondary to a Minor Blunt Chest Trauma |
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| Maximilian Andreas Storz,Eric P. Heymann,Aristomenis K. Exadaktylos | | Case Reports in Emergency Medicine. 2017; 2017: 1 | | [Pubmed] | [DOI] | | | 56 |
Pediatric Spontaneous Pneumomediastinum |
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| Celine Rey-Bellet Gasser,Rachel Pellaton,Cosette Pharisa Rochat | | Pediatric Emergency Care. 2017; 33(5): 370 | | [Pubmed] | [DOI] | | | 57 |
Neumomediastino espontáneo: revisión de tema |
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| María Piedad Londoño Duarte,Lina María Ávila Arenas | | Universitas Médica. 2017; 58(4) | | [Pubmed] | [DOI] | | | 58 |
Spontaneous pneumomediastinum: experience in 18 patients during the last 12 years |
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| Patrícia Dionísio,Luís Martins,Susana Moreira,Alda Manique,Rita Macedo,Fátima Caeiro,Luísa Boal,Cristina Bárbara | | Jornal Brasileiro de Pneumologia. 2017; (0) | | [Pubmed] | [DOI] | | | 59 |
Spontaneous pneumomediastinum. Case report |
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| Sebastian Felipe Sierra Umaña,Andrés Garcés Arias,Andrés Fernando Rodríguez Gutiérrez,Diego Fernando López Donato,Luisa Fernanda Patiño Unibio,Laura Marcela Velásquez Gaviria,Laura Salazar Franco,Sebastián Salinas Mendoza,Luis David Sáenz Pérez,Cristian Alejandro Castillo Rodríguez | | Case reports. 2017; 3(2): 91 | | [Pubmed] | [DOI] | | | 60 |
Clinical Approach for the Pneumomediastinum after Blunt Chest Trauma |
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| Onder Kavurmaci,Tevfik Ilker Akcam,Ali Ozdil,Ayse Gul Ergonul,Kutsal Turhan,Alpaslan Cakan,Ufuk Cagirici | | Open Journal of Thoracic Surgery. 2017; 07(01): 8 | | [Pubmed] | [DOI] | | | 61 |
Clinical Manifestations of Spontaneous Pneumomediastinum |
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| Soo Jin Park,Ji Ye Park,Joonho Jung,Seong Yong Park | | The Korean Journal of Thoracic and Cardiovascular Surgery. 2016; 49(4): 287 | | [Pubmed] | [DOI] | | | 62 |
THE MANY FACES OF PNEUMOMEDIASTINUM: AN OBSERVATIONAL STUDY |
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| Narendra Kumar Narahari,Anu Kapoor,Mohammed Ismail Nizami | | Journal of Evidence Based Medicine and Healthcare. 2016; 3(51): 2598 | | [Pubmed] | [DOI] | | | 63 |
An Unusual Association in an Uncommon Disease: Two Cases of Spontaneous Pneumomediastinum Associated with Pneumorrhachis |
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| Luís Martins,Patrícia Dionísio,Susana Moreira,Alda Manique,Isabel Correia,Cristina Bárbara | | Case Reports in Pulmonology. 2016; 2016: 1 | | [Pubmed] | [DOI] | | | 64 |
Presence of subpleural pulmonary interstitial emphysema as an indication of single or multiple alveolar ruptures on CT in patients with spontaneous pneumomediastinum |
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| Hye Rin Kim,Seung Min Yoo,Hwa Yeon Lee,Jin Hee Han,Aletta A Frazier,Charles S White | | Acta Radiologica. 2016; 57(12): 1483 | | [Pubmed] | [DOI] | | | 65 |
Blunt chest trauma with pneumomediastinum and pneumoperitoneum secondary to Macklin effect. Case report |
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| Héctor Alejandro Carzolio-Trujillo,Fernando Navarro-Tovar,César Isaac Padilla-Gómez,Iván Arturo Hernández-Martínez,Javier Herrera-Enríquez | | Cirugía y Cirujanos (English Edition). 2016; | | [Pubmed] | [DOI] | | | 66 |
Trauma contuso de tórax con neumomediastino y neumoperitoneo secundario a efecto Macklin. Reporte de un caso |
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| Héctor Alejandro Carzolio-Trujillo,Fernando Navarro-Tovar,César Isaac Padilla-Gómez,Iván Arturo Hernández-Martínez,Javier Herrera-Enríquez | | Cirugía y Cirujanos. 2016; | | [Pubmed] | [DOI] | | | 67 |
Three Simultaneous Cases of Spontaneous Pneumomediastinum With Epidural Pneumatosis During Vocal Training |
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| Yuki Yoshimatsu,Kazushi Yamairi,Kazutaka Nakasone,Michiru Sasaki,Saori Terai,Naoki Nakamura,Naomi Maruyama,Yae Yoshida,Munetake Takata,Natsuko Iwae,Kenichiro Otani,Takao Kamimori,Hiroshi Fujiwara | | Journal of Voice. 2016; | | [Pubmed] | [DOI] | | | 68 |
Pneumomediastinum: Can we tell prognosis upon presentation? |
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| Xina Lo,Wing-Hang Kwong,Heng-Tat Leong | | Surgical Practice. 2015; 19(3): 106 | | [Pubmed] | [DOI] | | | 69 |
Characteristics of pediatric noniatrogenic pneumomediasinum |
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| Narae Lee,Seung Kook Son,Hyung Young Kim,Hye-Young Kim,Hee Ju Park | | Allergy, Asthma & Respiratory Disease. 2015; 3(2): 145 | | [Pubmed] | [DOI] | | | 70 |
Spontaneous Pneumomediastinum: A Rare Disease Associated with Chest Pain in Adolescents |
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| Sung Hoon Kim,June Huh,Jinyoung Song,I-Seok Kang | | Yonsei Medical Journal. 2015; 56(5): 1437 | | [Pubmed] | [DOI] | | | 71 |
Spontaneous Pneumomediastinum in a Pediatric Patient After a 1600-m Run: Case Report and Literature Review |
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| CPT Zachary C. Booms,MAJ George A. Barbee | | Journal of Osteopathic Medicine. 2015; 115(5): 338 | | [Pubmed] | [DOI] | | | 72 |
Is primary spontaneous pneumomediastinum a truly benign entity? |
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| Sang Cjeol Lee,Deok Heon Lee,Gun-Jik Kim | | Emergency Medicine Australasia. 2014; : n/a | | [Pubmed] | [DOI] | | | 73 |
Spontaneous Pneumomediastinum with a Rare Presentation |
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| Ehsan Bolvardi,Elham Pishbin,Mohsen Ebrahimi,Azadeh Mahmoudi Gharaee,Farhad Bagherian | | Case Reports in Emergency Medicine. 2014; 2014: 1 | | [Pubmed] | [DOI] | | | 74 |
Pneumomediastinum in Blunt Chest Trauma: A Case Report and Review of the Literature |
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| Gregory Mansella,Roland Bingisser,Christian H. Nickel | | Case Reports in Emergency Medicine. 2014; 2014: 1 | | [Pubmed] | [DOI] | |
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