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Year : 2013  |  Volume : 5  |  Issue : 1  |  Page : 51-57

Evaluation of total antioxidant capacity of saliva in type 2 diabetic patients with and without periodontal disease: A case-control study

1 Department of Periodontics, Rural Dental College, Loni, Karnataka, India
2 Department of Pedodontics, Rural Dental College, Loni, Karnataka, India
3 Department of Periodontics, A.B. Shetty Memorial Institute of Dental Sciences, Mangalore, Karnataka, India

Correspondence Address:
Gowri Pendyala
Department of Periodontics, Rural Dental College, Loni, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1947-2714.106208

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Background: Diabetes mellitus (DM) has been linked with oxidative stress and decreased antioxidant defense. A connection has been established between diabetes and periodontal disease. Aim: The aim of present study was to compare salivary total antioxidant capacity of type 2 DM patients and healthy subjects with and without periodontal disease. Materials and Methods: A total of 120 subjects consisting of 30 type 2 DM patients with periodontal disease; 30 type 2 DM patients without periodontal disease; 30 healthy subjects with periodontal disease; 30 healthy subjects without periodontal disease were included in the study. After clinical measurement and samplings, total antioxidant capacity in saliva of type 2 diabetic and healthy subjects were determined, and the data were tested by non-parametric tests. Total antioxidant capacity of the clinical samples was determined spectrophotometrically. Results: The mean salivary total antioxidant capacity was lowest in diabetic patients with periodontitis. Conclusion: Total antioxidant capacity is inversely proportional to the severity of inflammation and can be used as an useful marker of periodontitis in healthy and diabetic patients.

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