Correlation of severity of coronary artery disease with insulin resistance

Mukund P Srinivasan; Padmanabh K Kamath; Poornima A Manjrekar; B Unnikrishnan; Aishwarya Ullal; Mohammed Faheem Kotekar; Chakrapani Mahabala

doi:10.4103/1947-2714.120799

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ORIGINAL ARTICLE

Year : 2013 | Volume : 5 | Issue : 10 | Page : 611-614

Correlation of severity of coronary artery disease with insulin resistance

Mukund P Srinivasan¹, Padmanabh K Kamath², Poornima A Manjrekar³, B Unnikrishnan⁴, Aishwarya Ullal⁵, Mohammed Faheem Kotekar⁵, Chakrapani Mahabala¹
¹ Department of Internal Medicine, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India
² Department of Cardiology, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India
³ Department of Biochemistry, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India
⁴ Department of Community Medicine, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India
⁵ Jr. Resident, Department of Internal Medicine, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India

Correspondence Address:
Chakrapani Mahabala
Department of Internal Medicine, Kasturba Medical College, Manipal University, Mangalore, Karnataka
India

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/1947-2714.120799

Background: Insulin resistance (IR) has known to be associated with coronary artery disease (CAD), but the assessment of severity of the CAD based on IR in type 2 diabetes mellitus has not been established in detail. Aims: The aim of our study was to establish the correlation between IR and the severity of CAD in type 2 diabetes mellitus. Materials and Methods: In a cross-sectional study design, 61 consecutive patients with type 2 diabetes mellitus who underwent coronary angiogram for the evaluation of CAD were recruited. Fasting blood glucose, fasting insulin levels, systolic blood pressure and total cholesterol/high density lipoprotein-cholesterol ratio were determined. Homeostasis model assessment-IR (HOMA-IR) was correlated with severity of CAD, which was measured by modified Gensini Score. Results: There was a significant correlation between log HOMA-IR and severity of CAD (r = 0.303, P = 0.009) in diabetic patients. Correlation of the Gensini Score with other known risk factors was not significant. Conclusions: The results of our study indicate that we might able to predict the severity of CAD by measure of IR.

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