| ORIGINAL ARTICLE |
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| Year : 2012 | Volume
: 4
| Issue : 6 | Page : 257-265 |
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Immune reactivity in psoriatic Munro-Saboureau microabscesses, stratum corneum and blood vessels
Ana Maria Abreu Velez1, Paul B Googe2, Michael S Howard1
1 Georgia Dermatopathology Associates, Atlanta, Georgia, USA
2 Knoxville Dermatopathology Laboratory, Knoxville, Tennessee, USA
Correspondence Address:
Ana Maria Abreu Velez
Georgia Dermatopathology Associates, 1534 North Decatur Rd., NE; Suite 206; Atlanta, Georgia 30307-1000
USA
 Source of Support: Georgia Dermatopathology Associates, Atlanta, Georgia, Conflict of Interest: None  | Check |
DOI: 10.4103/1947-2714.97204
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Background: A characteristic feature of early active psoriatic lesions is the intraepidermal penetration of neutrophils, with attendant formation of Munro-Saboureau microabscesses. Previous immunofluorescence studies have shown reactivity of in vivo binding of stratum corneum antibodies (SCAs) within the Munro-Saboreau microabscesses in cases of psoriasis. Aims: In our study, we aimed to investigate any correlation between the SCAs and the Munro-Saboureau microabscesses. Materials and Methods: We investigated 50 archival biopsies of psoriasis with Munro-Saboureau microabscesses, and attempted to confirm antibody colocalization within these microabcesses via immunohistochemistry staining. As controls, we utilized 50 skin biopsies from healthy patients undergoing esthetic plastic surgery procedures. Results: Within the Munro-Saboureau microabscesses, the following markers were statistically significantly positive relative to controls: CD1a, CD8, CD23, cyclooxygenase-2, myeloid histoid antigen, albumin, fibrinogen, kappa, lambda, von Willebrand factor, IgG, IgM, IgD, complement/C3c, C3d, myeloperoxidase, and carcinoembryonic antigen (P < 0.05). Autoreactivity to blood vessels was also detected, with multiple immunoglobulins and complement factors. Conclusions: We document important correlations between the Munro-Saboureau microabscesses, SCAs, and other immunoreactants. |
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