Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Visit old site
Home Print this page Email this page Small font size Default font size Increase font size
Users Online: 393
Year : 2012  |  Volume : 4  |  Issue : 2  |  Page : 90-93

Drug-induced hepatotoxicity in a tertiary care hospital in Rural South India

1 Pharmacology Unit, MAHSA University College, Jalan Elmu Off Jalan University, Kuala Lumpur, Malaysia
2 Department of Pharmacology, Sri Devaraj Urs Medical College, Kolar, Karnataka, India
3 Biochemistry Unit, MAHSA University College, Jalan Elmu Off Jalan University, Kuala Lumpur, Malaysia

Correspondence Address:
Heethal Jaiprakash
Department of Pharmacology, MAHSA University College, Jalan Elmu off Jalan University, Kuala Lumpur
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1947-2714.93385

Rights and Permissions

Background: Liver is the main organ for metabolism of drugs and hepatotoxicity is a potential adverse effect for most drugs. Aims: This study was to study the frequency of drug-induced hepatotoxicity and to find the common drugs causing hepatotoxicity. Materials and Methods: The study was conducted at a tertiary care hospital in rural India. It is a study based on case series analysis. All patients with an abnormal liver function report, between July 2006 and July 2007, were included in the study. Results : The study included 411 patients. Among them 141 patients were females and 270 males. The common cause for abnormal liver function was alcoholic liver disease (30.4%) followed by drug-induced hepatotoxicity (15.8%) and malaria (15.3%). Drug-induced hepatotoxicity was seen in 65 patients. It was common in males (55%) compared to females (44%). The mean age of the patients with drug-induced hepatotoxicity was 43±15.9. Antitubercular drugs were the commonly encountered drugs (44%) causing hepatotoxicity followed by lipid lowering agents (41%). The others drugs included antiretroviral drugs (6%),steroids (5%) and chlorpromazine (2%). Conclusion : A thorough history of drug intake must be taken in all patients presenting with abnormal hepatic function.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded407    
    Comments [Add]    
    Cited by others 7    

Recommend this journal