| ORIGINAL ARTICLE |
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| Year : 2012 | Volume
: 4
| Issue : 2 | Page : 86-89 |
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Vitamin E supplementation with Rauwolfia vomitoria root bark extract improves hematological indices
Akpanabiatu Monday Isaiah1, Otitoju Olawale1, Edet Emmanuel Effiong2, Ndem Jessie Idongesit1, Uwah Anthony Fidelis1, Ufot Usenobong Friday3
1 Department of Biochemistry, College of Basic Medical Sciences, University of Uyo, Uyo, Nigeria
2 Department of Biochemistry, College of Basic Medical Sciences, University of Calabar, Calabar, Nigeria
3 Department of Biological Sciences, Faculty of Natural and Applied Sciences, Akwa Ibom State University, P.M.B. 1167, Uyo, Nigeria
Correspondence Address:
Akpanabiatu Monday Isaiah
Department of Biochemistry, College of Basic Medical Sciences, University of Uyo, P. M. B. 1017, Uyo
Nigeria
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/1947-2714.93383
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Background: Vitamin supplementation in Rauwolfia vomitoria root bark extract administration may interact and impact significantly on hematology of albino Wistar rats. Aim : In this investigation we studied vitamin E supplementation with Rauwolfia vomitoria root bark extract on the hematology of experimental animals. Materials and Methods: Forty two rats weighing 200 - 230 g were randomly selected into six groups of seven animals each. Group 1 animals serve as controls; group 2 received vitamin E (10 IU/kg body weight). Groups 3 and 4 were given the extract (150 and 300 mg/kg body weight) respectively. Groups 5 and 6 were given vitamin E (10 IU/kg body weight), the extract (150 and 300 mg/kg body weight) respectively. The extract and the vitamin were administered daily by oral intubation. Blood samples analyzed for hematological indices. Results : Decrease in white blood cell count (WBC) was observed, indicating improved immunity of animals. Extract at 150 and 300 mg/kg body weight with and without vitamin E affected hemoglobin and packed cell volume. Conclusion : Rauwolfia vomitoria with or without vitamin E improved animal's immunity and enhances their hematology. Interaction of vitamin E with the extract affects medicinal therapeutics of this plant. |
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