Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Visit old site
Home Print this page Email this page Small font size Default font size Increase font size
Users Online: 501
Year : 2011  |  Volume : 3  |  Issue : 5  |  Page : 222-226

New insights into procathepsin D in pathological and physiological conditions

1 Kentucky Spinal Cord Injury Centre, Department of Neurological Surgery, Louisville, KY 40202, USA
2 Department of Pathology, University of Louisville, Louisville, KY 40202, USA

Correspondence Address:
Vaclav Vetvicka
Department of Pathology, University of Louisville, 511 S. Floyd St., Louisville, KY 40292
Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

Procathepsin D is a major glycoprotein that is secreted from numerous types of cancer cells including breast, lung and prostrate carcinomas. It affects multiple stages of tumorigenesis that include proliferation, invasion, metastasis and apoptosis. Previous studies showed that the mitogenic effect of procathepsin D on cancer cells was mediated through its propeptide or activation peptide. Recent studies have also implicated the possible use of procathepsin D/activation peptide as a marker of cancer progression. Considering the broad range of functions of procathepsin D, the present review summarizes the three major potentials of procathepsin D-cancer progression, tumor marker and wound healing.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded248    
    Comments [Add]    

Recommend this journal