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ORIGINAL ARTICLE
Year : 2011  |  Volume : 3  |  Issue : 4  |  Page : 176-178

No association between Val158Met of the COMT gene and susceptibility to schizophrenia in the Syrian population

Bassam Lajin1, Amal Alachkar2, Abdul Rezzak Hamzeh3, Roula Michati4, Hamid Alhaj5
1 Department of Analytical Chemistry, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria
2 Department of Pharmacology, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria
3 Department of Biochemistry, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria
4 Ibn Khaldoon Psychiatric Hospital, Aleppo, Syria
5 Academic Psychiatry, Newcastle General Hospital, Newcastle NE4 6BE, United Kingdom

Correspondence Address:
Bassam Lajin
Department of Analytical Chemistry, Faculty of Pharmacy, University of Aleppo, Aleppo
Syria
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Source of Support: None, Conflict of Interest: None


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Background : The Val158Met single nucleotide polymorphism of the COMT gene has been implicated in the aetiology of schizophrenia, although results from different populations have been conflicting. Aims: The aim of the present study was to investigate possible association between schizophrenia and Val158Met in a novel Arab population from Syria. Methods and Materials: 71 unrelated schizophrenic subjects (45 men) and 102 unrelated healthy controls (62 men) were recruited to take part in this case- control study. The Val158Met of the COMT gene was genotyped for patients and controls, using a new optimized PCR-RFLP method. Results: the results demonstrated that there is no statistically significant difference between the two groups. Conclusion: This study does not support that Val158Met has an influence on susceptibility for schizophrenia in this population.


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