| ORIGINAL ARTICLE |
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| Year : 2011 | Volume
: 3
| Issue : 12 | Page : 565-569 |
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Urinary tract infections caused by staphylococcus aureus DNA in comparison to the candida albicans DNA
Harith Jabbar Fahad Al-Mathkhury, Saba Nazeih Abdul-Ghaffar
Department of Biology, College of Science, University of Baghdad, Baghdad, Iraq
Correspondence Address:
Harith Jabbar Fahad Al-Mathkhury
Assistant Professor, Department of Biology, College of Science, University of Baghdad, Baghdad
Iraq
 Source of Support: None, Conflict of Interest: None  | Check |
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Background : Bacterial DNA released upon bacterial autolysis or killed by antibiotics, hence, many inflammatogenic reactions will be established leading to serious tissue damage. Aim : the present work aimed to elucidate the histopathological changes caused by prokaryotic (bacterial) DNA and eukaryotic (candidal) DNA. Materials and Methods : twenty one Staphylococcus aureus and 36 Candida albicans isolates were isolated from UTI patients. Viable cells and DNA of the highest antibiotic sensitive isolates were injected, intraurethraly, in mice. Results were evaluated via histopathological examination. Results: Mildest reactions were obtained from mice challenged with viable C. albicans compared with those challenged with viable S. aureus. Dose-dependent histological changes were observed for both eukaryotic and prokaryotic DNA. However, the eukaryotic C. albicans DNA developed less intense histological changes than S. aureus DNA. Conclusion: microbial DNA has the ability to cause damage in murine renal system. Nevertheless, bacterial DNA caused more intense damage than candidal DNA. |
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